Repair fabric roof repair sealants the home depot store finder.
Gutter patch material.
This guide explains how to fix gutter leaks specifically when repairing a small or large hole in metal gutters.
If it is large use a piece of galvanized metal flashing.
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If the hole is small you can use plastic roofing cement.
If you have a large area to patch that s damaged or rusted your best solution may be to cut that section of guttering away with a hacksaw.
Then cut a new section slightly larger than the one you removed and adhere it two both sides of the old gutter using roofing cement to hold and seal it.